This is the reason for the bigger risk of sudden death in people using alcohol and coke or crack together. If you're on anti-depressants check with a doctor before using these drugs. Rubbing coke into the arse hole will make it numb and irritate the skin.
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Useful to Know If you share straws or bank notes to snort coke tiny amounts of blood could go from the lining of one preson's nose to another.