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The orexin neurons also innervate cholinergic and noncholinergic neurons in the basal forebrain and project directly to the cortex. The team led by de Lecea and Sutcliffe 2 named the peptides hypocretin-1 and -2 because they are produced in the hypothalamus and have some similarities to the incretin family of peptides. Orexin antagonists, especially those that block OX2 or both OX1 and OX2 receptors, clearly promote sleep in animals, and clinical results are encouraging:

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